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Rare tumors: a blue ocean of investigation
Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 220-230 doi: 10.1007/s11684-023-0984-z
Keywords: rare tumors diagnosis flowchart treatment strategy clinical trials recommendation
Clinical trials of the new 3-dimensional reticular intrauterine device for reproductive women
Qiu Yi,Wang Leiguang and Yu Ling
Strategic Study of CAE 2014, Volume 16, Issue 5, Pages 39-46
This study aimed at exploring a new 3-dimensional reticular intrauterine device (3-DR-IUD) composed of nitinol and silicone rubber and observing the contraceptive efficacy and side effects of the device in reproductive women. The frame of the 3-DR-IUD was constructed with silicone rubber and nitinol wire. The 3-DR-IUD was placed into uterus in an outpatient procedure. One hundred and fifty- two women were divided equally into the 3-DR-IUD group (n=76) and the 2- dimensional intrauterine device (2- D- IUD) group (n=76,control group). Patient follow-ups were performed in 1~12 months post-operation. The side effects of intrauterine device (IUD),such as abnormal leucorrhea,menstrual flow changes in uterine bleeding profusely and pain,etc,were investigated. The pregnancy rate,expulsion rate,removal rate of IUD for medical reasons and the continuation rate were evaluated. The ultrasound and pelvic X-ray were carried out to examine IUDs. The results showed that two groups with 76 cases of each successfully placed IUD and there were no severe pain during the operation. The incidence of lumbago/abdominal pain and the occurrence of leucorrhea and irregular vaginal bleeding in the 3-DR-IUD group (7.9 %,6/76) were significantly lower than that of the 2-DIUD group (40.8 %,31/76) during the first 12 months for use of IUD (P<0.000 1). The pregnancy rate,expulsion rate and take-off rate due to symptom were 0 %,0 % and 1.3 % in 3-DRIUD group,respectively,and 1 of 76 woman take-off 3-DR-IUD was due to allergy for silicon rubber. The continuation rate was 98.7 % (75/76) in the 3-DR-IUD group,comparing with the 2-D-IUD group (86.8 % ,66/76),the difference was significantly (P=0.009). Therefore,the 3-DR-IUD demonstrates long-term patient tolerability,satisfaction and efficacy as a contraceptive.The 3-DR-IUD appears to be a new,safe and effective devise of contraception.
Keywords: 3-DR-IUD clinical trials side effects contraceptive efficacy
Overcoming the challenges of conducting translational research in cell therapy
Sowmya Viswanathan, Armand Keating
Frontiers of Medicine 2011, Volume 5, Issue 4, Pages 333-335 doi: 10.1007/s11684-011-0166-2
Keywords: stem cells clinical trials funding animal models standardization common definitions
Frontiers of Medicine 2022, Volume 16, Issue 5, Pages 736-744 doi: 10.1007/s11684-021-0870-5
Keywords: pneumoconiosis randomized controlled trials traditional Chinese medicine
Next Steps for Efficacy Evaluation in Clinical Trials of COVID-19 Vaccines
Hu-Dachuan Jiang, Li Zhang, Jing-Xin Li, Feng-Cai Zhu
Engineering 2021, Volume 7, Issue 7, Pages 903-907 doi: 10.1016/j.eng.2021.04.013
Wenjie Zhu, Binghe Xu
Frontiers of Medicine 2021, Volume 15, Issue 2, Pages 208-220 doi: 10.1007/s11684-020-0795-4
Keywords: endocrine-resistant HR+/HER2- advanced breast cancer randomized clinical trials
Zhaoxiang Bian, Baoyan Liu, David Moher, Taixiang Wu, Youping Li, Hongcai Shang, Chungwah Cheng
Frontiers of Medicine 2011, Volume 5, Issue 2, Pages 171-177 doi: 10.1007/s11684-011-0132-z
Keywords: CONSORT for TCM reporting standards future development
Jiang Guoliang
Strategic Study of CAE 2009, Volume 11, Issue 10, Pages 129-136
This report consists of two parts: basic study and clinical trial forAnd 3 clinical trials have been carried out, which yielded encouraging outcome with 3-year rvivals oftechnique of HCC irradiation,which is fit to Chinese HCC,has been successfully applied in a series of clinicaltrials.It demonstrates that radiation therapy is one of the treatment choices for medically inoperable
Keywords: 3-dimensional conformal radiation therapy intensity modulated radiation therapy epatocellular carcinoma liver irradiation tolerance
Non-IID Recommender Systems: A Review and Framework of Recommendation Paradigm Shifting Artical
Longbing Cao
Engineering 2016, Volume 2, Issue 2, Pages 212-224 doi: 10.1016/J.ENG.2016.02.013
While recommendation plays an increasingly critical role in our living, study, work, and entertainmentIn this paper, the non-IID nature and characteristics of recommendation are discussed, followed by thetheoretical framework in order to build a deep and comprehensive understanding of the intrinsic nature of recommendationThis non-IID recommendation research triggers the paradigm shift from IID to non-IID recommendation research
Keywords: relationship Coupling learning Relational learning IIDness learning Non-IIDness learning Recommender system Recommendation Non-IID recommendation
Current State of Monoclonal Antibody Therapy for Allergic Diseases Review
Yan Chen, Wei Wang, Huihui Yuan, Yan Li, Zhe Lv, Ye Cui, Jie Liu, Sun Ying
Engineering 2021, Volume 7, Issue 11, Pages 1552-1556 doi: 10.1016/j.eng.2020.06.029
Keywords: Allergic disease Monoclonal antibody Anti-IgE Cytokines Clinical trials
Toward Privacy-Preserving Personalized Recommendation Services Review
Cong Wang, Yifeng Zheng, Jinghua Jiang, Kui Ren
Engineering 2018, Volume 4, Issue 1, Pages 21-28 doi: 10.1016/j.eng.2018.02.005
Recommendation systems are crucially important for the delivery of personalized services to users.With personalized recommendation services, users can enjoy a variety of targeted recommendations suchIn addition, personalized recommendation services have become extremely effective revenue drivers forWe present the general architecture of personalized recommendation systems, the privacy issues therein, and existing works that focus on privacy-preserving personalized recommendation services.
Keywords: Privacy protection Personalized recommendation services Targeted delivery Collaborative filtering Machine
Quality Control and Nonclinical Research on CAR-T Cell Products: General Principles and Key Issues Review
Yonghong Li, Yan Huo, Lei Yu, Junzhi Wang
Engineering 2019, Volume 5, Issue 1, Pages 122-131 doi: 10.1016/j.eng.2018.12.003
Keywords: Chimeric antigen receptor T cells Quality control Nonclinical research Safety Efficacy Clinicaltrials Cancer immunotherapy
PAN Jiangang, ZHOU Xing, CHEN Zhiguang, HAN Ruifa
Frontiers of Medicine 2008, Volume 2, Issue 3, Pages 259-263 doi: 10.1007/s11684-008-0049-3
A microblog recommendation algorithm based on social tagging and a temporal interest evolution model
Zhen-ming YUAN,Chi HUANG,Xiao-yan SUN,Xing-xing LI,Dong-rong XU
Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 7, Pages 532-540 doi: 10.1631/FITEE.1400368
Keywords: Recommender system Collaborative filtering Social tagging Interest evolution model
Core Outcome Set for Clinical Trials on Coronavirus Disease 2019 (COS-COVID) Article
Xinyao Jin, Bo Pang, Junhua Zhang, Qingquan Liu, Zhongqi Yang, Jihong Feng, Xuezheng Liu, Lei Zhang, Baohe Wang, Yuhong Huang, Alice Josephine Fauci, Yuling Ma, Myeong Soo Lee, Wei’an Yuan, Yanming Xie, Jianyuan Tang, Rui Gao, Liang Du, Shuo Zhang, Hanmei Qi, Yu Sun, Wenke Zheng, Fengwen Yang, Huizi Chua, Keyi Wang, Yi Ou, Ming Huang, Yan Zhu, Jiajie Yu, Jinhui Tian, Min Zhao, Jingqing Hu, Chen Yao, Youping Li, Boli Zhang
Engineering 2020, Volume 6, Issue 10, Pages 1147-1152 doi: 10.1016/j.eng.2020.03.002
Since its outbreak in December 2019, a series of clinical trials on coronavirus disease 2019 (COVIDHowever, the significant heterogeneity and less critical outcomes of such trials may be leading to aThis study aimed to develop a core outcome set (COS) for clinical trials on COVID-19 in order to tackleThe study was conducted according to the Core Outcome Measures in Effectiveness Trials (COMET) Handbookclassifications of COVID-19 were identified and determined to constitute the COS for clinical trials
Keywords: Novel coronavirus pneumonia Core outcome set COVID-19 2019-nCoV Coronavirus disease Clinical trials
Title Author Date Type Operation
Clinical trials of the new 3-dimensional reticular intrauterine device for reproductive women
Qiu Yi,Wang Leiguang and Yu Ling
Journal Article
Overcoming the challenges of conducting translational research in cell therapy
Sowmya Viswanathan, Armand Keating
Journal Article
Clinical efficacy of comprehensive therapy based on traditional Chinese medicine patterns on patients
Journal Article
Next Steps for Efficacy Evaluation in Clinical Trials of COVID-19 Vaccines
Hu-Dachuan Jiang, Li Zhang, Jing-Xin Li, Feng-Cai Zhu
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Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor receptor 2-negative (HR
Wenjie Zhu, Binghe Xu
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Consolidated standards of reporting trials (CONSORT) for traditional Chinese medicine: current situation
Zhaoxiang Bian, Baoyan Liu, David Moher, Taixiang Wu, Youping Li, Hongcai Shang, Chungwah Cheng
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Three-dimensional conformal and intensity modulated radiation therapy for hepatocellular carcinoma:basic study and clinicaltrials
Jiang Guoliang
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Non-IID Recommender Systems: A Review and Framework of Recommendation Paradigm Shifting
Longbing Cao
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Current State of Monoclonal Antibody Therapy for Allergic Diseases
Yan Chen, Wei Wang, Huihui Yuan, Yan Li, Zhe Lv, Ye Cui, Jie Liu, Sun Ying
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Toward Privacy-Preserving Personalized Recommendation Services
Cong Wang, Yifeng Zheng, Jinghua Jiang, Kui Ren
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Quality Control and Nonclinical Research on CAR-T Cell Products: General Principles and Key Issues
Yonghong Li, Yan Huo, Lei Yu, Junzhi Wang
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A meta-analysis of randomized trials of maintenance bacillus Calmette-Guerin instillation efficacy against
PAN Jiangang, ZHOU Xing, CHEN Zhiguang, HAN Ruifa
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A microblog recommendation algorithm based on social tagging and a temporal interest evolution model
Zhen-ming YUAN,Chi HUANG,Xiao-yan SUN,Xing-xing LI,Dong-rong XU
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Core Outcome Set for Clinical Trials on Coronavirus Disease 2019 (COS-COVID)
Xinyao Jin, Bo Pang, Junhua Zhang, Qingquan Liu, Zhongqi Yang, Jihong Feng, Xuezheng Liu, Lei Zhang, Baohe Wang, Yuhong Huang, Alice Josephine Fauci, Yuling Ma, Myeong Soo Lee, Wei’an Yuan, Yanming Xie, Jianyuan Tang, Rui Gao, Liang Du, Shuo Zhang, Hanmei Qi, Yu Sun, Wenke Zheng, Fengwen Yang, Huizi Chua, Keyi Wang, Yi Ou, Ming Huang, Yan Zhu, Jiajie Yu, Jinhui Tian, Min Zhao, Jingqing Hu, Chen Yao, Youping Li, Boli Zhang
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